British Air Force Typhoon FGR4s have joined forces with French warplanes in a coordinated attack targeting an underground arms cache in Syria used by the IS group, as stated by the UK's MoD.
The site, located using intelligence, was assessed as housing weapons and explosive materials, the release indicated, and was positioned in hills just north of the ancient city of Palmyra in central Syria.
"The RAF jets used precision-guided Paveway IV munitions to hit a number of access tunnels leading to the depot... early reports indicate the objective was successfully hit," the ministry announced.
There was no sign of any harm to civilians in the attack conducted Saturday night and all the aircraft returned to base without incident, the MoD added.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
IS - alternatively referred to as the so-called Islamic State - enforced militant control over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This action shows our UK leadership, and determination to operate in unison with our allies, to eliminate any revival of the terrorist group and their dangerous and violent ideologies in the region," the British Defence Secretary John Healey said.
British military aircraft have carried out patrols over Syrian airspace to "forestall any efforts to regroup" of IS after its routing at the Baghuz confrontation in 2019, the ministry said.
"I want to thank the personnel of British forces participating in this mission for their skill and their courage," he added. "Including them were thousands of British personnel deployed over Christmas and New Year. This action, to remove militants who pose a risk to our security, shows how UK forces are ready to step up, all year round, ensuring Britain's security domestically and influential overseas."
In December, the US military executed what it called a "major assault" targeting Islamic State objectives in Syria, subsequent to an assault claimed the lives of two American soldiers and a local interpreter in Palmyra.
The United Nations says IS still boasts between 5,000 and 7,000 militants in both countries.